Laboratory PI
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Research Area & additional information
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Ju Chen, PhD
Professor of Medicine
AHA Endowed Chair
Director of Basic Cardiac Research
School of Medicine
UC San Diego
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Dr. Chen’s laboratory investigates cardiac and skeletal muscle myopathies. His research focuses on disease associated mutations to sarcomere-associated proteins. Projects in his lab revolve around myofibrillar and sarcomere associated proteins, such as FHL1, Cypher, and use genetic, physiological and biochemical techniques.
More information can be found on the lab homepage.
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Stephan Lange, PhD
Assistant Professor
School of Medicine
UC San Diego
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Dr. Lange’s research is focused on studying muscle development, signaling and maintenance, by studying the biological role of sarcomeric and muscle associated proteins. Research projects in Dr. Lange’s laboratory investigate signaling pathways that at are responsible for the development of dilated cardiomyopathy, and which involve cardiac functions of muscle ankyrin repeat proteins. Students would be trained in biochemical, cell-biological, molecular and genetic techniques to investigate functions of cardiac signaling pathways.
More information can be found on the lab homepage.
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Jeff Omens, PhD
Professor
Department of Bioengineering
UC San Diego
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Dr. Omen is interested in biomechanics of cardiac contraction and cardiac disease mechanisms. Projects in his lab investigate passive and active mechanics of the normal and diseased hearts, instrumentation development for biomechanical and functional measurements in the mouse heart, and computational modeling of cardiac function.
More information can be found on the lab homepage.
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Nicole Purcell, PhD
Assistant Professor
School of Medicine
UC San Diego
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Dr. Purcell studies different aspects of cerebrovascular and cardiovascular physiology, principally focusing on changes in cellular signaling due to phosphatase removal in normal physiology and disease states. Students working on projects in Dr. Purcell’s laboratory would receive training in physiology, molecular and cell-biology.
More information can be found on the lab homepage.
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Farah Sheikh, PhD
Associate Professor
School of Medicine
UC San Diego
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Dr. Sheikh’s work evolves around molecular mechanisms for the development of arrhythmogenic right ventricular cardiomyopathy. Projects in her lab investigate proteins of the cardiac intercalated disc, specifically proteins of the desmosome complex that are involved in the disease mechanism.
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