Difference between revisions of "Model organisms"
From SDMRC
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MDX mutant mice do not express dystrophin and are used as a model system for Duchenne Muscular Dystrophy. <br /> | MDX mutant mice do not express dystrophin and are used as a model system for Duchenne Muscular Dystrophy. <br /> | ||
More information: [http://jaxmice.jax.org/strain/001801.html More information on the mouse model (JAX lab)]<br /> | More information: [http://jaxmice.jax.org/strain/001801.html More information on the mouse model (JAX lab)]<br /> | ||
| − | '''Human disease''': [http://en.wikipedia.org/wiki/Duchenne_muscular_dystrophy Duchenne Muscular Dystrophy] | + | '''Human disease''': [http://en.wikipedia.org/wiki/Duchenne_muscular_dystrophy Duchenne Muscular Dystrophy]<br /> |
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Contact: Alessandra Sacco | Contact: Alessandra Sacco | ||
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MDX mice lacking the RNA component of telomerase (mdx/mTR) have shortened telomeres in muscle cells and severe muscular dystrophy that progressively worsens with age.<br /> | MDX mice lacking the RNA component of telomerase (mdx/mTR) have shortened telomeres in muscle cells and severe muscular dystrophy that progressively worsens with age.<br /> | ||
Read the publication [http://www.ncbi.nlm.nih.gov/pubmed/21145579 here].<br /> | Read the publication [http://www.ncbi.nlm.nih.gov/pubmed/21145579 here].<br /> | ||
| − | '''Human disease''': [http://en.wikipedia.org/wiki/Duchenne_muscular_dystrophy Duchenne Muscular Dystrophy] | + | '''Human disease''': [http://en.wikipedia.org/wiki/Duchenne_muscular_dystrophy Duchenne Muscular Dystrophy]<br /> |
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Contact: Alessandra Sacco | Contact: Alessandra Sacco | ||
Revision as of 18:59, 9 November 2014
This site contains a list of model organisms to study human myopathies. Please feel free to edit/amend the list.
Mdx mutation
MDX mutant mice do not express dystrophin and are used as a model system for Duchenne Muscular Dystrophy.
More information: More information on the mouse model (JAX lab)
Human disease: Duchenne Muscular Dystrophy
Contact: Alessandra Sacco
mdx/mTR
MDX mice lacking the RNA component of telomerase (mdx/mTR) have shortened telomeres in muscle cells and severe muscular dystrophy that progressively worsens with age.
Read the publication here.
Human disease: Duchenne Muscular Dystrophy
Contact: Alessandra Sacco
